|Title||Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Bego, T, Dujić, T, Mlinar, B, Semiz, S, Malenica, M, Prnjavorac, B, Ostanek, B, Marc, J, Čaušević-Ramoševac, A, Causevic, A|
|Journal||Med Glas (Zenica)|
|Date Published||2015 Aug|
|Keywords||Adult, Body Mass Index, Bosnia and Herzegovina, Hemoglobin A, Glycosylated, Humans, Metabolic Syndrome X, Middle Aged, Phosphatidate Phosphatase, Polymorphism, Genetic|
AIM: To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference, body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina.
METHODS: This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: C>T and rs2716610: C>T) by real time PCR method.
RESULTS: In control subjects LPIN1 polymorphism, rs2716610: C>T, was significantly associated with a lower body mass index (BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: C>T polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients.
CONCLUSION: Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.
|Alternate Journal||Med Glas (Zenica)|